发明授权
- 专利标题： Gastrin releasing peptide antagonist
- 专利标题（中）： 胃泌素释放肽拮抗剂
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申请号： US343092申请日： 1989-04-25
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公开(公告)号： US5028692A公开(公告)日： 1991-07-02
- 发明人: Allen I. Oliff , Walfred S. Saari
- 申请人： Allen I. Oliff , Walfred S. Saari
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： C07K7/02
- IPC分类号： C07K7/02 ; C07K7/08 ; C07K14/575
摘要：
Small cell lung carcinoma cells (SCLC) contain gastrin releasing peptide (GRP) receptors. The response of the cells to GRP is rapid growth. We have found a group of peptide derivatives that act as GRP antagonists by blocking the binding of GRP to its receptor thereby inhibiting the growth of cells that are sensitive to the growth promoting activity of GRP.
公开/授权文献
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