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发明授权
US5036106A Methods for the treatment of disorders of the cardiac vascular system 失效
治疗心脏血管系统疾病的方法

Methods for the treatment of disorders of the cardiac vascular system
摘要：
Methods are described to utilize synergistic interactions by various combinations of (1) bethanidine and various tricyclic compounds, (2) bethanidine and bretylium tosylate, (3) bretylium tosylate and various tricyclic compounds, and (4) debrisoquin sulfate and various tricyclic compounds, preferably in a single injectable or oral dosage form, to prevent, treat, and reduce the vulnerability of the heart to ventricular fibrillation and other ventricular arrhythmias in animals, both human and otherwise. Also, the use of bethanidine and bretylium tosylate in combination, and the use of debrisoquin sulfate for the resuscitation of pulseless beings, the use of debrisoquin sulfate for the suppression of ventricular fibrillation and ventricular tachycardia, and the use of bethanidine as an antidote to tricyclic antidepressant toxicity are disclosed.
摘要（中）：

描述了通过各种组合使用（1）β-han啶和各种三环化合物，（2）bet han啶和甲苯磺酸ret by，，，，preferably preferably preferably preferably preferably preferably preferably preferably preferably utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize utilize 以单一的可注射或口服剂型形式，以预防，治疗和降低人类和其他方面的心脏对心室颤动和其他室性心律失常的易感性。 此外，组合使用了bethanidine和甲苯磺酸甲苯磺酸盐，并且使用硫酸瓦来昔沙星复苏无脉动物，使用硫酸瓦糖代谢抑制心室纤维性颤动和室性心动过速，以及使用bethanidine作为三环的解毒剂 公开了抗抑郁药物的毒性。

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