A spray-drying granulation apparatus having: a spray drying section formed in an upper position of a chamber wherein sprayed feed liquid particles are dried to powder by a hot-air; and a powder granulation section formed in a power position of the chamber, and provided with a nozzle for feeding a binder liquid. There is no need of maintaining sticky powder or completely dried powder to the lower section. The sprayed particles can be dried to powder in a wide drying range before they are granulated in the granulation section by a binder liquid. The degree of granulation can be selected as desired while preventing attachment of powder to the inner wall of the chamber due to incomplete drying.