发明授权
US5047433A N-alkyl derivatives of 2-amino-6,7-dimethoxy tetraline and
pharmaceutical compositions having antihypertensive activity containing
same
失效
2-氨基-6,7-二甲氧基四氢萘的N-烷基衍生物和含有其的抗高血压活性的药物组合物
- 专利标题： N-alkyl derivatives of 2-amino-6,7-dimethoxy tetraline and pharmaceutical compositions having antihypertensive activity containing same
- 专利标题（中）： 2-氨基-6,7-二甲氧基四氢萘的N-烷基衍生物和含有其的抗高血压活性的药物组合物
-
申请号： US135335申请日： 1987-12-21
-
公开(公告)号： US5047433A公开(公告)日： 1991-09-10
- 发明人: Mauro Marzi , Maria O. Tinti , Romano Di Fabio , Domenico Misiti
- 申请人： Mauro Marzi , Maria O. Tinti , Romano Di Fabio , Domenico Misiti
- 申请人地址： ITX Rome
- 专利权人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人地址： ITX Rome
- 优先权： ITX48779A/86 19861223
- 主分类号： C07C217/74
- IPC分类号： C07C217/74 ; A61K31/13 ; A61K31/135 ; A61P9/12 ; C07C67/00 ; C07C213/00 ; C07C213/02
摘要：
N-alkyl derivatives of 2-amino-6,7-dimethoxy tetraline having general formula (I) ##STR1## wherein R is selected from hydrogen, ethyl, n-propyl and methyl cyclopropyl;R.sub.1 is selected from hydrogen, hydroxy and --OR.sub.3 wherein R.sub.3 is selected from methyl, ethyl and n-propyl; andR.sub.2 is selected from hydrogen, methyl, hydroxy, trifluoromethyl, fluoro and methoxy,are endowed with potent antihypertensive activity.
公开/授权文献
信息查询
