发明授权
- 专利标题: N-heterocyclo-substituted p-aminophenols
- 专利标题(中): N-杂环取代的P-氨基苯酚
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申请号: US409192申请日: 1989-09-19
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公开(公告)号: US5059598A公开(公告)日: 1991-10-22
- 发明人: Kenichi Kanai , Kiyoto Goto , Kinji Hashimoto
- 申请人: Kenichi Kanai , Kiyoto Goto , Kinji Hashimoto
- 申请人地址: JPX Naruto
- 专利权人: Otsuka Pharmaceutical Factory, Inc.
- 当前专利权人: Otsuka Pharmaceutical Factory, Inc.
- 当前专利权人地址: JPX Naruto
- 优先权: JPX61-172431 19860721; JPX61-213660 19860910; JPX62-38595 19870220; JPX62-94199 19870416
- 主分类号: C07D231/38
- IPC分类号: C07D231/38 ; C07D237/20 ; C07D239/42 ; C07D241/20 ; C07D249/04 ; C07D249/08 ; C07D249/14 ; C07D253/07 ; C07D261/14 ; C07D263/48 ; C07D285/10 ; C07D285/12 ; C07D285/135 ; C07D333/36 ; C07D333/38
摘要:
Disclosed are compounds of the formula ##STR1## wherein: R.sup.1 is a lower alkyl group;R.sup.2 and R.sup.3 are each hydrogen or lower alkyl or R.sup.2 and R.sup.3 taken together may form --(CH.sub.2).sub.4 -- or --CH.dbd.CH--CH.dbd.CH--;.alpha. is a 5- or 6-membered heretoaromatic ring group containing 1 to 3 hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur, or a pyrazine-N-oxide ring, pyridazine-N-oxide ring or pyrimidine -N-oxide ring group, wherein each of these heteroaromatic ring groups may optionally have 1 to 3 substituents selected from the group consisting of a lower alkyl halogen, phenyl, lower alkoxycarbonyl, amino, lower alkoxy and hydroxy-lower alkyl, with the proviso that said 5- or 6-membered heteroaromatic ring group is not thiazolyl, isothiazolyl, pyridyl or 1,3,5-triazinyl group; or salts thereof. These compounds and salts thereof have anti-inflammatory activity and lipoxygenase-inhibitory activity.