Invention Grant
US5061803A Process for making 17-beta alkanoyl 3-oxo-4-aza-5-.alpha.-androst-1-enes
失效
制备17-β链烷酰基3-氧代-4-氮杂-5α-雄甾-1-烯的方法
- Patent Title: Process for making 17-beta alkanoyl 3-oxo-4-aza-5-.alpha.-androst-1-enes
- Patent Title (中): 制备17-β链烷酰基3-氧代-4-氮杂-5α-雄甾-1-烯的方法
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Application No.: US587299Application Date: 1990-09-24
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Publication No.: US5061803APublication Date: 1991-10-29
- Inventor: John M. Williams
- Applicant: John M. Williams
- Applicant Address: NJ Rahway
- Assignee: Merck & Co., Inc.
- Current Assignee: Merck & Co., Inc.
- Current Assignee Address: NJ Rahway
- Main IPC: A61K31/56
- IPC: A61K31/56 ; A61P13/02 ; A61P15/00 ; C07J73/00 ; C07J75/00
Abstract:
Disclosed is a new process for making 17-beta branched alkanoyl-3-oxo-4-aza-5-.alpha.-androst-1-enes, agents for treating benign prostatic hypertrophy (BPH), by reacting methyl 3-oxo-4-aza-5-.alpha.-androst-1-ene-17-beta carboxylate with isobutylmagnesium bromide in the novel presence of the hexamethyldisilazane (HMDS). Use of the HMDS results in higher yield and less by-products as opposed to the standard Grignard reaction in the absence of HMDS.
Public/Granted literature
- US5764783A Variable beamwidth transducer Public/Granted day:1998-06-09
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