发明授权
- 专利标题: Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
- 专利标题(中): 用于治疗神经疾病的假体和抗骨质蛋白多糖连接物
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申请号: US508874申请日: 1990-04-12
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公开(公告)号: US5066828A公开(公告)日: 1991-11-19
- 发明人: Philippe Bey , H. Michael Kolb
- 申请人: Philippe Bey , H. Michael Kolb
- 申请人地址: OH Cincinnati
- 专利权人: Merrell Dow Pharmaceuticals Inc.
- 当前专利权人: Merrell Dow Pharmaceuticals Inc.
- 当前专利权人地址: OH Cincinnati
- 主分类号: A61K31/505
- IPC分类号: A61K31/505 ; A61K31/519 ; A61P35/00 ; C07C229/24 ; C07C233/83 ; C07C237/36 ; C07D471/04 ; C07D475/02 ; C07D475/04 ; C07D475/06 ; C07D475/08
摘要:
This invention relates to certain conjugates of folates and antifolates with difluoroglutamic acid which are useful in the treatment of patients suffering from certain neoplastic diseases including leukemia, melanomas, carcinomas, sarcomas and mixed neoplasias.
公开/授权文献
- US4613176A Door latch mechanism 公开/授权日:1986-09-23
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