发明授权
US5075435A Beta-lactams and their production via stereospecific hydrogenation
失效
BETA-LACTAMS及其通过立体加氢的生产
- 专利标题: Beta-lactams and their production via stereospecific hydrogenation
- 专利标题(中): BETA-LACTAMS及其通过立体加氢的生产
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申请号: US537149申请日: 1990-06-12
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公开(公告)号: US5075435A公开(公告)日: 1991-12-24
- 发明人: Makoto Sunagawa , Haruki Matsumura , Tsuneo Yano , Akira Sasaki , Shinzi Takata
- 申请人: Makoto Sunagawa , Haruki Matsumura , Tsuneo Yano , Akira Sasaki , Shinzi Takata
- 申请人地址: JPX Osaka
- 专利权人: Sumitomo Pharmaceuticals Company, Limited
- 当前专利权人: Sumitomo Pharmaceuticals Company, Limited
- 当前专利权人地址: JPX Osaka
- 优先权: JPX59-230790 19841031; JPX60-5912 19850118
- 主分类号: C07D205/08
- IPC分类号: C07D205/08 ; C07D498/04
摘要:
A beta-lactam compound of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom, a lower alkyl group or a 1-hydroxy(lower)alkyl group wherein the hydroxyl group is optionally protected, R.sub.2 is a hydrogen atom or a protective group for the nitrogen atom and R.sub.3 is a methyl group, a halomethyl group, a hydroxymethyl group, a protected hydroxymethyl group, a formyl group, a carboxyl group, a lower alkoxycarbonyl group or an ar(lower)alkoxycarbonyl group wherein the aryl group is optionally substituted, or R.sub.2 and R.sub.3 are combined together to form an oxaalkylene group and, when taken together with one nitrogen atom and two carbon atoms adjacent thereto, they represent a six-membered cyclic aminoacetal group, which is useful as a valuable intermediate in the stereospecific production of 1-methylcarbapenem compounds.
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