An electrophotographic printing plate precursor which comprises a conductive support having provided thereon, in order, an intermediate layer and an electrophotographic photo-receptive layer, wherein the intermediate layer contains at least one compound having at least one amino group and at least one group selected from the group consisting of a carboxyl group, a sulfo group and a hydroxyl group, or a salt of the compound, whereby ink stains are prevented from sticking to the non-image area upon printing.