发明授权
US5091367A Analogs of gonadoliberin with improved solubility, methods for their
preparation, agents containing them and their use
失效
具有改善溶解性的甘油二醇的模拟物，其制备方法，包含它们的试剂及其用途
- 专利标题： Analogs of gonadoliberin with improved solubility, methods for their preparation, agents containing them and their use
- 专利标题（中）： 具有改善溶解性的甘油二醇的模拟物，其制备方法，包含它们的试剂及其用途
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申请号： US724477申请日： 1991-06-28
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公开(公告)号： US5091367A公开(公告)日： 1992-02-25
- 发明人: Wolfgang Konig , Jurgen K. Sandow , Cenek Kolar
- 申请人： Wolfgang Konig , Jurgen K. Sandow , Cenek Kolar
- 申请人地址： DEX Frankfurt am Main
- 专利权人： Hoechst Aktiengesellschaft
- 当前专利权人： Hoechst Aktiengesellschaft
- 当前专利权人地址： DEX Frankfurt am Main
- 优先权： DEX3634435 19861009
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K38/04 ; A61P5/00 ; A61P9/12 ; C07K7/06 ; C07K7/23 ; C07K9/00 ; C07K14/575
摘要：
The invention relates to peptides of the formula ##STR1## in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg of His; E is D-Ser(R.sup.1), .beta.-Asn, .beta.-Asp-OMe, D-Thi or --NH--CH(CH.sub.2 R.sup.2)--CO--; F is Ser(R.sup.1), Leu, Trp or Phe; G is Gly-NH.sub.2, Aza-Gly-NH.sub.2, D-Ala-NH.sub.2 or NH-alkyl; R.sup.1 is glycosyl and R.sup.2 is hydrogen, acyl, aryl or heteroaryl.The invention also relates to methods for the preparation of these peptides, agents containing them and their use.
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