发明授权
- 专利标题: P-acylaminophenoxycarbamates and derivatives
- 专利标题(中): 对氨基苯甲酸甲酯和衍生物
-
申请号: US566291申请日: 1990-07-30
-
公开(公告)号: US5109011A公开(公告)日: 1992-04-28
- 发明人: Richard C. Allen , Raymond W. Kosley, Jr. , Bettina Spahl
- 申请人: Richard C. Allen , Raymond W. Kosley, Jr. , Bettina Spahl
- 申请人地址: NJ Somerville
- 专利权人: Hoechst-Roussel Pharmaceuticals Incorporated
- 当前专利权人: Hoechst-Roussel Pharmaceuticals Incorporated
- 当前专利权人地址: NJ Somerville
- 主分类号: A61K31/215
- IPC分类号: A61K31/215 ; A61K31/27 ; A61K31/415 ; A61K31/44 ; A61K31/4409 ; A61P25/04 ; C07C271/40 ; C07C271/42 ; C07C271/44 ; C07D213/54 ; C07D213/79 ; C07D233/60 ; C07D521/00
摘要:
This invention relates to p-acylaminophenoxycarbamates having the formula ##STR1## where R.sub.1 and R.sub.2 are each independently hydrogen, loweralkyl, aryl and arylloweralkyl; R.sub.3 is hydrogen, loweralkyl, aryllowerallkyl; R.sub.4 is hydrogen, loweralkyl, formyl, alkylcarbonyl, arylloweralkyl, phenylcarbonyl, arylloweralkylcarbonyl, substituted phenylcarbonyl, pyridylcarbonyl, and substituted pyridylcarbonyl with the proviso that if R.sub.4 contains a carbonyl group directly attached to the oxygen of the N-O moiety, R.sub.3 cannot by hydrogen; or R.sub.3 and R.sub.4 taken together form a heterocyclic ring selected from the group consisting of imidazole or loweralkylimidazole; X is hydrogen, halogen, hydroxy, loweralkyl, loweralkoxy, nitro, amino or trifluoromethyl; and p is an integer selected from 0 and 1; the pharmaceutically acceptable acid addition salts thereof, and where applicable, the geometric and stereoisomers and racemic mixtures thereof. The compounds of this invention display utility as analgesics.
公开/授权文献
信息查询