发明授权
- 专利标题： Process for the preparation of a carbocyclic nucleoside analogue
- 专利标题（中）： 制备碳氢化合物核苷类似物的方法
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申请号： US553631申请日： 1990-07-18
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公开(公告)号： US5110926A公开(公告)日： 1992-05-05
- 发明人: Richard Storer , Chi L. Mo , John P. Turnbull
- 申请人： Richard Storer , Chi L. Mo , John P. Turnbull
- 申请人地址： GB2 London
- 专利权人： Glaxo Group Limited
- 当前专利权人： Glaxo Group Limited
- 当前专利权人地址： GB2 London
- 优先权： GBX8916480 19890719
- 主分类号： C07D473/16
- IPC分类号： C07D473/16 ; C07D473/00 ; C07D473/18 ; C07D473/34 ; C07D487/14 ; C07H19/16
摘要：
A process is described for the preparation of carbocyclic guanosine from aristeromycin in a multi-step procedure, the final step of which is the hydrolysis of a compound of the formula ##STR1## wherein R.sup.1 represents a C.sub.1-6 alkyl group or an arylC.sub.1-4 alkyl group and R.sup.2, R.sup.3 and R.sup.4 each independently represent a hydrogen atom or a hydroxyl protecting group.Carbocyclic guanosine is an intermediate in the synthesis of carbocyclic analogues of nucleosides having use in therapy, particularly as antiviral agents.
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