发明授权
- 专利标题： 4-imidazoline derivatives
- 专利标题（中）： 4-咪唑啉衍生物
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申请号： US514832申请日： 1990-04-26
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公开(公告)号： US5116858A公开(公告)日： 1992-05-26
- 发明人: Yoshio Hayashi , Yasuhiro Morinaka , Masaki Shinoda , Hiroyoshi Nishi , Kazutoshi Watanabe , Nobuko Fukushima
- 申请人： Yoshio Hayashi , Yasuhiro Morinaka , Masaki Shinoda , Hiroyoshi Nishi , Kazutoshi Watanabe , Nobuko Fukushima
- 申请人地址： JPX Tokyo
- 专利权人： Mitsubishi Kasei Corporation
- 当前专利权人： Mitsubishi Kasei Corporation
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX1-107028 19890426
- 主分类号： A61K31/415
- IPC分类号： A61K31/415 ; A61P25/28 ; A61P43/00 ; C07D233/70
摘要：
4-Imidazoline derivatives represented by the formula (I) and/or formula (II): ##STR1## wherein R.sup.1 represents C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 alkenyl, C.sub.3 -C.sub.8 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, or optionally substituted aralkyl; R.sup.2 and R.sup.3 independently represent hydrogen, C.sub.3 -C.sub.20 alkyl, C.sub.3 -C.sub.20 alkenyl, C.sub.3 -C.sub.20 alkynyl, C.sub.3 -C.sub.20 alkoxy, C.sub.3 -C.sub.20 alkenyloxy, C.sub.3 -C.sub.20 alkynyloxy, C.sub.3 -C.sub.8 cyloalkyl, C.sub.1 -C.sub.10 alkylthio, or optionally substituted aralkyl or aralkyloxy; R.sup.4 represents C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.8 cycloalkyl, or optionally substituted aralkyl; provided that R.sup.2 and R.sup.3 cannot be hydrogen at the same time, and pharmaceutically acceptable salts thereof. A pharmaceutical formulation containing the compound is also provided.