发明授权
US5124337A N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme
a:cholesterol acyl transferase
失效
N-酰基 - 四氢异喹啉作为酰基辅酶a：胆固醇酰基转移酶的抑制剂
- 专利标题： N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase
- 专利标题（中）： N-酰基 - 四氢异喹啉作为酰基辅酶a：胆固醇酰基转移酶的抑制剂
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申请号： US702993申请日： 1991-05-20
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公开(公告)号： US5124337A公开(公告)日： 1992-06-23
- 发明人: Sundeep Dugar , Timothy Kogan
- 申请人： Sundeep Dugar , Timothy Kogan
- 申请人地址： NJ Kenilworth
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： NJ Kenilworth
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; A61K31/472 ; A61P3/06 ; A61P9/10 ; C07D217/06 ; C07D217/14 ; C07D217/18 ; C07D217/20
摘要：
N-acyltetrahydroisoquinolines including novel compounds of the formula ##STR1## wherein R.sup.1 is a C10-C25 alkyl chain; a substituted C10-C25 alkyl chain; an interrupted C10-C25 alkyl chain; a substituted interrupted C10-C25 alkyl chain; diphenylamino; di-(R.sup.2 -substituted phenyl)amino; di-(heteroaryl)amino; di-R.sup.2 -substituted heteroary)amino; diphenylmethyl; or di-(R.sup.2 -substituted phenyl)methyl;R.sup.2 is hydroxy, lower alkyl, lower alkoxy, halogeno, amino, lower alkylamino or di-(lower alkyl)amino;R.sup.3, R.sup.4 and R.sup.5 are independently H or --(CH.sub.2 .sub.n --Ar;Ar is phenyl, R.sup.2 -substituted phenyl, heteroaryl or R.sup.2 -substituted heteroaryl;n=0,1 or 2;m=0,1 or 2;or a pharmaceutically acceptable salt thereof, useful in the treatment of atherosclerosis are disclosed.
公开/授权文献
- US5903788A Camera 公开/授权日：1999-05-11
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