发明授权
- 专利标题: Carbacyclins, process for the preparation thereof, and use thereof as medicinal agents
- 专利标题(中): 卡巴菌素,其制备方法及其作为药剂的用途
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申请号: US141233申请日: 1988-01-06
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公开(公告)号: US5124343A公开(公告)日: 1992-06-23
- 发明人: Helmut Vorbrueggen , Hernd Raduechel , Werner Skuballa , Norbert Schwarz , Jorge Casals-Stenzel , Gerda Mannesmann , Michael H. Town
- 申请人: Helmut Vorbrueggen , Hernd Raduechel , Werner Skuballa , Norbert Schwarz , Jorge Casals-Stenzel , Gerda Mannesmann , Michael H. Town
- 申请人地址: DEX Berlin & Bergkamen
- 专利权人: Schering Aktiengesellschaft
- 当前专利权人: Schering Aktiengesellschaft
- 当前专利权人地址: DEX Berlin & Bergkamen
- 优先权: DEX3306125 19830218
- 主分类号: C07C45/59
- IPC分类号: C07C45/59 ; C07C57/26 ; C07C57/60 ; C07C405/00 ; C07D263/14 ; C07D317/72 ; C07F9/40
摘要:
The invention relates to carbacyclins of general Formula I ##STR1## wherein R.sub.1 is the residue CH.sub.2 OH or ##STR2## with R.sub.2 meaning a hydrogen atom, an alkyl, cycloalkyl, aryl residue, a ##STR3## or heterocyclic residue, or R.sub.1 is the residue ##STR4## with R.sub.3 meaning an alkanoyl or alkanesulfonyl residue of respectively 1-10 carbon atoms or the residue R.sub.2, orR.sub.1 is the residue ##STR5## wherein m is the number 1 or 2, X is an oxygen atom or a CH.sub.2 -group,A is a trans--CH.dbd.CH- or --.tbd.C--group,W is a free or functionally modified hydroxymethylene group wherein the OH-group can be in the .alpha.- or .beta.- position,n is the number 1, 2, or 3,D is a straight-chain alkylene group of 1-5 carbon atoms,E is a --C.tbd.C---bond or a --CR.sub.6 =CR.sub.7 --group wherein R.sub.6 and R.sub.7 are different from each other and mean a hydrogen atom or an alkyl group of 1-5 carbon atoms or a hydrogen atom or a halogen atom, preferably chlorine,R.sub.4 is an alkyl, cycloalkyl, or optionally substituted arly group, or a heterocyclic group,R.sub.5 is a free or functionally modified hydroxy group, andif R.sub.2 means a hydrogen atom, the salts thereof with physiologically compatible bases;to processes for the preparation thereof, and to the use thereof as blood-pressure-lowering agents.
公开/授权文献
- US5580960A KS-laminin and methods of use 公开/授权日:1996-12-03