发明授权
- 专利标题: Triazolo derivatives and process for their preparation
- 专利标题(中): TRIAZOLO衍生物及其制备方法
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申请号: US604486申请日: 1990-10-25
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公开(公告)号: US5135928A公开(公告)日: 1992-08-04
- 发明人: Jozsef Reiter , Jozsef Barkoczy , Lujza Petocz , Frigyes Gorgenyi , Marton Fekete , Eniko Szirt nee Kiszelly , Gabor Gigler , Istvan Gacsalyi , Istvan Gyertyan , Klara Reiter nee Esses
- 申请人: Jozsef Reiter , Jozsef Barkoczy , Lujza Petocz , Frigyes Gorgenyi , Marton Fekete , Eniko Szirt nee Kiszelly , Gabor Gigler , Istvan Gacsalyi , Istvan Gyertyan , Klara Reiter nee Esses
- 申请人地址: HUX Budapest
- 专利权人: Egis Gyogyszergyar
- 当前专利权人: Egis Gyogyszergyar
- 当前专利权人地址: HUX Budapest
- 优先权: HUX5427/89 19891025; HUX5429/89 19891025
- 主分类号: A61K31/41
- IPC分类号: A61K31/41 ; A61K31/50 ; A61K31/535 ; A61K31/55 ; A61P9/08 ; A61P9/10 ; A61P29/00 ; C07D249/14 ; C07D403/04 ; C07D405/12 ; C07D413/04 ; C07D487/04
摘要:
This invention relates to novel triazolo derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said triazolo derivatives for the treatment of diseases and also for the preparation of pharmaceutical compositions suitable for the treatment of the said diseases.The new triazolo derivatives of the general formulae (Ia) and (Ib), ##STR1## wherein Q represents hydrogen or a heterocyclic group optionally bearing one or more C.sub.1-4 alkyl substituent(s); or a group of the formula SR.sup.1, whereinR.sup.1 stands for straight or branched chained C.sub.1-4 alkyl or phenyl-(C.sub.1-4 alkyl); or q represents a group of the formula NR.sup.2 R.sup.3, whereinR.sup.2 and R.sup.3 each represent hydrogen, straight or branched chain C.sub.1-12 alkyl, C.sub.2-6 alkenyl or phenyl-(C.sub.1-4 alkyl);R.sup.4 and R.sup.7 each represent hydrogen, C.sub.1-6 alkyl or phenyl-(C.sub.1-4 alkyl) optionally bearing one or more halogen substituent(s);R.sup.5 and R.sup.6 each stand for C.sub.1-4 alkyl optionally substituted by a C.sub.1-4 alkoxycarbonyl group; a heterocyclic group or a phenyl group optionally bearing one or more halogen, hydroxyl, cyano, nitro, alkyl, methylene dioxy and carbamoylmethoxy, di-(C.sub.1-4 alkyl)-amino or C.sub.1-4 alkoxy substituent(s) which latter may carry a di-(C.sub.1-4 alkyl)-amino group; furthermore one of R.sup.5 and R.sup.6 may represent hydrogen, orR.sup.5 and R.sup.6 together stand for C.sub.4-15 alkylene, or together with the adjacent carbon atom they are attached to form a heterocyclic group bearing a phenyl(C.sub.1-4 alkyl) substituent,possess valuable antianginal and tranquillant/sedative properties and are useful in therapy.