发明授权
- 专利标题: 4-azahexacyclododecane compounds
- 专利标题(中): 4-AZAHEXACYCLODODECANE化合物
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申请号: US628512申请日: 1990-12-13
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公开(公告)号: US5137908A公开(公告)日: 1992-08-11
- 发明人: Theunis G. Fourie , Friedrich O. Snyckers
- 申请人: Theunis G. Fourie , Friedrich O. Snyckers
- 申请人地址: ZAX Pretoria
- 专利权人: Noristan Holdings Limited
- 当前专利权人: Noristan Holdings Limited
- 当前专利权人地址: ZAX Pretoria
- 优先权: ZAX89/9513 19891213
- 主分类号: C07D487/08
- IPC分类号: C07D487/08
摘要:
4-Azahexacyclo (5.4.1.0.sup.2,6 .0.sup.3,10 .0.sup.5,9 .0.sup.8,11) dodecane compounds of the formula ##STR1## wherein R, A and B each is hydrogen; a linear or branched alkyl group having one to twelve carbon atoms and optionally including a hydroxyl or halogen substituent; or a phenyl group alone or optionally substituted with a linear or branched alkyl group having one to twelve carbons, which group optionally includes a hydroxyl or halogen substituent; and X is a hydroxyl or --NR.sub.2 group where R is as stated above; or an acid addition salt of such compound. These compounds are useful in pharmaceutical compositions wherein the compound is included in an amount effective to be used as a calcium antogonist, a cardiac agent or an anti-hypertensive agent.
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