发明授权
US5137919A Effect of N,N,N,-trimethylsphingosine on protein kinase C activity
melanoma cell growth in vitro; metastatic potential in vivo and human
platelet aggregation
失效
N，N，N， - 三甲基鞘氨醇对蛋白激酶C活性的影响;体外黑素瘤细胞生长; 体内转移潜能和人血小板聚集
- 专利标题： Effect of N,N,N,-trimethylsphingosine on protein kinase C activity melanoma cell growth in vitro; metastatic potential in vivo and human platelet aggregation
- 专利标题（中）： N，N，N， - 三甲基鞘氨醇对蛋白激酶C活性的影响;体外黑素瘤细胞生长; 体内转移潜能和人血小板聚集
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申请号： US636353申请日： 1990-12-31
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公开(公告)号： US5137919A公开(公告)日： 1992-08-11
- 发明人: Yasuyuki Igarashi , Mahammad N. Ahmad , Hirofumi Okoshi , Sen-Itiroh Hakomori
- 申请人： Yasuyuki Igarashi , Mahammad N. Ahmad , Hirofumi Okoshi , Sen-Itiroh Hakomori
- 申请人地址： WA Seattle
- 专利权人： Biomembrane Institute
- 当前专利权人： Biomembrane Institute
- 当前专利权人地址： WA Seattle
- 主分类号： C07C215/40
- IPC分类号： C07C215/40
摘要：
The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors), and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory and anti-metastatic activity over related compounds.
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