发明授权
- 专利标题: Azole derivatives and anti-ulcerative composition containing same
- 专利标题(中): 唑衍生物和含有其的抗溃疡组合物
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申请号: US716622申请日: 1991-06-14
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公开(公告)号: US5141946A公开(公告)日: 1992-08-25
- 发明人: Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Naoki Yamazaki , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Motohiro Nishio , Tomoya Machinami , Seiji Shibahara , Takashi Tsuruoka , Shigeharu Inouye
- 申请人: Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Naoki Yamazaki , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Motohiro Nishio , Tomoya Machinami , Seiji Shibahara , Takashi Tsuruoka , Shigeharu Inouye
- 申请人地址: JPX Yokohama
- 专利权人: Meiji Seika Kabushiki Kaisha
- 当前专利权人: Meiji Seika Kabushiki Kaisha
- 当前专利权人地址: JPX Yokohama
- 优先权: JPX1-165244 19890629; JPX1-303366 19891124
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; A61K31/435 ; A61K31/44 ; A61K31/445 ; A61K31/495 ; A61K31/535 ; A61P1/04 ; C07D471/04 ; C07D498/04 ; C07D513/04
摘要:
Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in whichA, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.;X represents --NH--, --O-- or --S--;Y represents --(CH.sub.2).sub.p -- wherein p is an integer from 0 to 4, --C(CH.sub.3).sub.2 --, --CH.sub.2 CH.dbd.CH--, --CH.sub.2 CO--, --CF.sub.2 -- or --CH.sub.2 COCH.sub.2 --;R.sup.1 represents a hydrogen atom, a C.sub.1-4 alkyl group, a halogen atom or a C.sub.1-4 alkoxy group;R.sup.2 represnts a hydrogen atom, a hydroxyl group, a saturated or unsaturated C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a carboxyl group, a saturated or unsaturated C.sub.1-12 alkoxycarbonyl group which may be optionally substituted, a cycloalkoxycarbonyl group, a saturated or unsaturated five- or six-memebered heterocyclic group containing at least one nitrogen atom optionally with one or more nitrogen and/or oxygen atoms, which may be optionally condensed and/or substituted, --CONR.sup.3 R.sup.4, --NR.sup.3 R.sup.4, --OCOR.sup.3 or --NHCONHR.sup.3 wherein R.sup.3 and R.sup.4, which may be the same or different, represent a C.sub.1-6 alkyl group which may be optionally substituted or a cycloalkyl group, andm and n each represent an integrer from 0 to 2.The compounds are useful in treating ulcers.
公开/授权文献
- US5670710A Fluid quantity gauging systems 公开/授权日:1997-09-23