发明授权
US5141957A 1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for inhibiting protein
kinase C
失效
用于抑制蛋白激酶C的1,4-BIS-（氨基 - 羟基甲酰氨基） - 亚硝基
- 专利标题： 1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for inhibiting protein kinase C
- 专利标题（中）： 用于抑制蛋白激酶C的1,4-BIS-（氨基 - 羟基甲酰氨基） - 亚硝基
-
申请号： US609416申请日： 1990-11-05
-
公开(公告)号： US5141957A公开(公告)日： 1992-08-25
- 发明人: Jack B. Jiang , Mary G. Johnson
- 申请人： Jack B. Jiang , Mary G. Johnson
- 申请人地址： NC Durham
- 专利权人： Sphinx Pharmaceuticals Corporation
- 当前专利权人： Sphinx Pharmaceuticals Corporation
- 当前专利权人地址： NC Durham
- 主分类号： A61K31/135
- IPC分类号： A61K31/135 ; A61K31/165 ; A61K31/19 ; A61K31/24 ; A61P7/02 ; A61P9/00 ; A61P29/00 ; A61P35/00 ; A61P43/00 ; C07C20060101 ; C07C225/34 ; C07C225/36 ; C07C229/74 ; C07C237/06 ; C12N9/99
摘要：
The present invention provides novel substituted anthraquinones having the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently H, alkyl, aryl, or arylalkyl;m and n are independently 1, 2, or 3;X is H, OH, NR.sub.3 R.sub.4, Cl, Br, I, F, alkyl, aryl alkoxy, aroxy, COOR.sub.5, or CONR.sub.6 R.sub.7 ;R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are independently H, lower alkyl or aryluseful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.
公开/授权文献
信息查询
