A clamping arrangement for clamping a cylindrical shaft of a tool in a dental handpiece includes a clamping sleeve having resilient tongues for gripping the cylindrical shaft and being capable of being moved radially outward by an adjustable plunger to release the shaft. In order to achieve a largely wear-free tool guidance, the tool shaft is held at least at its distal end of the tool in a guide bushing, which is firmly joined to the hollow shaft. The guide contains an arrangement which enables axial mobility of the plunger, prevents twisting of the plunger so as to enable transmission of the force between the plunger and a manipulator which actuates the plunger.