发明授权
US5185341A Substituted 5-(phenoxyalkanoylamino)-uracil compounds, methods for
making same and pharmaceutical compositions based on same
失效
取代的5-(苯甲酰氨基)脲类化合物,其制备方法和基于同一物质的药物组合物
- 专利标题: Substituted 5-(phenoxyalkanoylamino)-uracil compounds, methods for making same and pharmaceutical compositions based on same
- 专利标题(中): 取代的5-(苯甲酰氨基)脲类化合物,其制备方法和基于同一物质的药物组合物
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申请号: US787064申请日: 1991-11-04
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公开(公告)号: US5185341A公开(公告)日: 1993-02-09
- 发明人: Wolfgang Sauer , Hans-Joachim Jansch , Angelika Rostock , Gottfried Faust , Christine Siegemund , Dieter Lohmann , Reni Bartsch
- 申请人: Wolfgang Sauer , Hans-Joachim Jansch , Angelika Rostock , Gottfried Faust , Christine Siegemund , Dieter Lohmann , Reni Bartsch
- 申请人地址: DEX Radebeul
- 专利权人: Arzneimittelwerk Dresden GMBH
- 当前专利权人: Arzneimittelwerk Dresden GMBH
- 当前专利权人地址: DEX Radebeul
- 优先权: DEX4035599 19901106
- 主分类号: A61K31/505
- IPC分类号: A61K31/505 ; A61P25/28 ; C07D239/54 ; C07D239/545
摘要:
The substituted 5-(phenoxyalkanoylamino)-uracil compounds have the following formula I: ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen; a branched or linear alkyl group having 1 to 6 carbon atoms; a branched or straight chain alkenyl or alkynyl group having 1 to 6 carbons atoms; a cycloalkyl group having from 3 to 7 carbon atoms or a cycloalkylmethyl group having a cycloalkyl residue of 3 to 7 carbon atoms; or a phenylalkyl group having an alkyl residue having from 1 to 3 carbon atoms and a phenyl residue, the phenyl residue being unsubstituted or having a halogen, methoxy, methyl or trifluoromethyl substituent; R.sub.3 is a hydrogen, methyl or amino groups; R.sub.4 is halogen, methoxy or methyl groups, and n is 1 or 2. Pharmaceutical compositions for treating cerebrovascular, neuronal-degenerative and senility-induced disorders associated with learning, memory and cognitive dysfunctions are described which contain a therapeutically effective amount of the substituted 5-(phenoxyalkanoylamino)-uracil in a pharmaceutically acceptable carrier.