发明授权
US5187175A 2-carbonyl substituted-5-hydroxy-1, 3-pyrimidines as antiinflammatory
agents
失效
2-羰基取代-5-羟基-1,3-嘧啶作为抗炎剂
- 专利标题： 2-carbonyl substituted-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents
- 专利标题（中）： 2-羰基取代-5-羟基-1,3-嘧啶作为抗炎剂
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申请号： US847511申请日： 1992-03-06
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公开(公告)号： US5187175A公开(公告)日： 1993-02-16
- 发明人: Thomas R. Belliotti , David T. Connor , Catherine R. Kostlan , Steven R. Miller
- 申请人： Thomas R. Belliotti , David T. Connor , Catherine R. Kostlan , Steven R. Miller
- 申请人地址： NJ Morris Plains
- 专利权人： Warner-Lambert Company
- 当前专利权人： Warner-Lambert Company
- 当前专利权人地址： NJ Morris Plains
- 主分类号： C07D239/36
- IPC分类号： C07D239/36 ; C07D403/06 ; C07D409/06 ; C07D417/06 ; C07F7/08
摘要：
The present invention is novel compounds which are 2-carbonyl substituted-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever and the like. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions.
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