发明授权
US5192759A Derivatives of 1,2,3,4-tetrahydronaphtylamine endowed with nootropic
activity and pharmaceutical compositions containing same
失效
具有非活性活性的1,2,3,4-四氢吡啶甲酰胺的衍生物和含有其的药物组合物
- 专利标题： Derivatives of 1,2,3,4-tetrahydronaphtylamine endowed with nootropic activity and pharmaceutical compositions containing same
- 专利标题（中）： 具有非活性活性的1,2,3,4-四氢吡啶甲酰胺的衍生物和含有其的药物组合物
-
申请号： US809874申请日： 1991-12-18
-
公开(公告)号： US5192759A公开(公告)日： 1993-03-09
- 发明人: Fabio Giannessi , Orlando Ghirardi , Domenico Misiti , Maria O. Tinti , Roberto Cozzolino
- 申请人： Fabio Giannessi , Orlando Ghirardi , Domenico Misiti , Maria O. Tinti , Roberto Cozzolino
- 申请人地址： ITX Rome
- 专利权人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人地址： ITX Rome
- 优先权： ITX48605A/90 19901221
- 主分类号： A61K31/135
- IPC分类号： A61K31/135 ; A61K31/195 ; A61P25/28 ; C07C229/22 ; C07C233/23 ; C07C237/04 ; C07C237/10 ; C07D207/16 ; C07D207/26 ; C07D207/27 ; C07D207/273 ; C07D207/28 ; C07D211/76 ; C07D223/10
摘要：
1,2,3,4-tetrahydronaphthlamines of formula (1) ##STR1## wherein R is H or OCH.sub.3 ; ##STR2## is either at 1 or 2 position R.sub.1 is H;R.sub.2 is selected from:L-prolyl, optionally N-substituted with acetyl or carbobenzoxy,L-pyroglutamyl,(pyrrolidin-2-one-1-yl)acetyl,3-carboxy-2-hydroxypropyl:or R.sub.1 and R.sub.2 taken together with the nitrogen atom form the ring ##STR3## wherein n=1,2,3 and R.sub.3 -H, OH are nootropic substances potent enhancers of learning processes and memory.Orally or parenterally administrable pharmaceutical compositions in unit dosage form comprise between about 100 and about 500 mg of a compound of formula (1).
公开/授权文献
信息查询
