发明授权
- 专利标题： Polysaccharide-protein conjugates
- 专利标题（中）： 多糖 - 蛋白质共轭物
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申请号： US155799申请日： 1988-02-16
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公开(公告)号： US5204098A公开(公告)日： 1993-04-20
- 发明人: Shousun C. Szu , Rachel Schneerson , John B. Robbins
- 申请人： Shousun C. Szu , Rachel Schneerson , John B. Robbins
- 申请人地址： DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： DC Washington
- 主分类号： A61K39/05
- IPC分类号： A61K39/05 ; A61K39/02 ; A61K39/08 ; A61K39/106 ; A61K39/112 ; A61K39/145 ; A61K39/385 ; A61K39/39 ; A61K39/395 ; A61K47/48 ; C07K17/10
摘要：
Vi capsular polysaccharides conjugated to toxin-dependent proteins can be used to enhance antibody response and to convert T-dependent properties to the Vi capsular polysaccharide. A heterobifunctional crosslinking agent can be used to bind thiol derivatives of the Vi capsular polysaccharides to the proteins, such as diphtheria, tetanus toxoids, cholera toxin and Haemophilus influenzae.
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