发明授权
US5204256A Process for the purification of plasminogen activator inhibitor 2 (PAI-2)
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纯化激活剂抑制剂2(PAI-2)的方法
- 专利标题: Process for the purification of plasminogen activator inhibitor 2 (PAI-2)
- 专利标题(中): 纯化激活剂抑制剂2(PAI-2)的方法
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申请号: US892634申请日: 1992-06-02
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公开(公告)号: US5204256A公开(公告)日: 1993-04-20
- 发明人: Klaus-Peter Radtke , Norbert Heimburger , Karlheinz Wenz
- 申请人: Klaus-Peter Radtke , Norbert Heimburger , Karlheinz Wenz
- 申请人地址: DEX Marburg
- 专利权人: Behringwerke Aktiengesellschaft
- 当前专利权人: Behringwerke Aktiengesellschaft
- 当前专利权人地址: DEX Marburg
- 优先权: DEX3929504 19890906
- 主分类号: C07K14/81
- IPC分类号: C07K14/81
摘要:
A process for the purification of plasminogen activator inhibitor 2 (PAI-2) including the steps of preincubating a PAI-2-containing solution with a compound which cleaves disulfide linkages, mixing the solution with a water-soluble acridine or quinoline base to precipitate impurities in the solution, and separating the precipitated impurities to obtain PAI-2 in purified form.
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