A multi-stage cyclone separator apparatus is provided for separating particulates from gas in a particulate laden gas. The apparatus is particularly useful for separating particulates such as catalyst particles from hot refinery gas in fluid catalytic cracking reactors and regenerators. The apparatus makes economical use of space and provides for accommodation of stresses due to differential temperature expansion by providing a manifold or plenum chamber receiving partially cleaned outlet gases from a first stage of cyclone separators and providing an inlet therefore to a second stage of separators. The number of separators in each stage are independent of those in the other stage. By arrangement around the periphery of the intermediate manifold chamber and suspension from a top of the housing the separators in the different stages may be efficiently interfitted without interference from separator dip legs as well as providing support for the structure to accommodate thermal stresses.