发明授权
US5221741A Process for the preparation of
9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-d
e][1,4]benzothiazine-6-carboxylic acid hydrochloride
失效
9-氟代-10-（4-甲基-1-哌啶子基）-7-氧代-2,3-二氢-7H-吡啶并[1,2-a]（1,4）苯并噻嗪 - 6-羧酸氢氯化物
- 专利标题： Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-d e][1,4]benzothiazine-6-carboxylic acid hydrochloride
- 专利标题（中）： 9-氟代-10-（4-甲基-1-哌啶子基）-7-氧代-2,3-二氢-7H-吡啶并[1,2-a]（1,4）苯并噻嗪 - 6-羧酸氢氯化物
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申请号： US889797申请日： 1992-05-29
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公开(公告)号： US5221741A公开(公告)日： 1993-06-22
- 发明人: Violetta Cecchetti , Arnaldo Fravolini , Pier Giuseppe Pagella , Fausto Schiaffella
- 申请人： Violetta Cecchetti , Arnaldo Fravolini , Pier Giuseppe Pagella , Fausto Schiaffella
- 申请人地址： ITX Milan
- 专利权人： Mediolanum Farmaceutici S.p.A.
- 当前专利权人： Mediolanum Farmaceutici S.p.A.
- 当前专利权人地址： ITX Milan
- 优先权： ITXMI91A001577 19910607
- 主分类号： A61K31/54
- IPC分类号： A61K31/54 ; A61P31/04 ; C07D513/06
摘要：
Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride (Rufloxacin) by reaction of 2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)benzoyl ethyl acetate with N,N-dimethylformamide dimethylacetal, followed by reaction with 2-aminoethanethiol, intramolecular cyclization by treatment with NaH, hydrolysis with H.sub.2 O and salification with HCl.
公开/授权文献
- US5949558A Holographic storage using shift multiplexing 公开/授权日：1999-09-07
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