The glyphs of a self-clocking glyph code for encoding n-bit long multi-bit digital values are preordered in a cyclical sequence, based on their analytically or empirically determined probabilities of being confused with each other, such that each glyph is adjacent in that sequence to the two glyphs with which it is more likely to be confused during decoding. Binary encoding values then are assigned to these ordered glyphs in accordance with an n-bit long Gray code sequence, so that the value assigned to any given glyph differs in just one bit position from the values assigned to the glyphs with which it is most likely to be confused.