发明授权
US5225335A 1,2-dehydrogenation of steroidal 21-esters with Arthrobacter simplex or
Bacterium cyclooxydans
失效
使用单节节杆菌或环孢菌素的甾体21-酯的1,2-脱氢
- 专利标题: 1,2-dehydrogenation of steroidal 21-esters with Arthrobacter simplex or Bacterium cyclooxydans
- 专利标题(中): 使用单节节杆菌或环孢菌素的甾体21-酯的1,2-脱氢
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申请号: US582954申请日: 1989-09-12
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公开(公告)号: US5225335A公开(公告)日: 1993-07-06
- 发明人: Leo A. Kominek , Holly J. Wolf , Paula S. Steiert
- 申请人: Leo A. Kominek , Holly J. Wolf , Paula S. Steiert
- 申请人地址: MI Kalamazoo
- 专利权人: The Upjohn Company
- 当前专利权人: The Upjohn Company
- 当前专利权人地址: MI Kalamazoo
- 主分类号: C07J5/00
- IPC分类号: C07J5/00 ; C07J13/00 ; C12P33/02
摘要:
The present invention involves processes for 1,2-dehydrogenation of .DELTA..sup.4 -3-keto C.sub.21 -hemiester steroids of formula (I) ##STR1## with Arthrobacter simplex or Bacterium cyclooxydans to produce the corresponding .DELTA..sup.1,4 -3-keto C.sub.21 hemiester of formula (II) ##STR2## or free alcohol thereof with improved yields. The advantage is that the processes utilize higher substrate concentrations and give shorter reaction times than previously were known.
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