发明授权
- 专利标题: Aminopropanol derivatives, process for their preparation and pharmaceutical compositions comprising the same
- 专利标题(中): 氨基丙醇衍生物,其制备方法和包含其的药物组合物
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申请号: US876091申请日: 1992-04-30
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公开(公告)号: US5234934A公开(公告)日: 1993-08-10
- 发明人: Zoltan Budai , Klara Reiter nee Esses , Eniko Sziri nee Kiszelly , Gizella Zsila , Gabor Gigler , Lujza Petocz , Maria Szecsey nee Hegedus , Marton Fekete , Valeria Hoffmann , Laszlo Kapolnai
- 申请人: Zoltan Budai , Klara Reiter nee Esses , Eniko Sziri nee Kiszelly , Gizella Zsila , Gabor Gigler , Lujza Petocz , Maria Szecsey nee Hegedus , Marton Fekete , Valeria Hoffmann , Laszlo Kapolnai
- 申请人地址: HUX Budapest
- 专利权人: Egis Gyogyszergyar
- 当前专利权人: Egis Gyogyszergyar
- 当前专利权人地址: HUX Budapest
- 优先权: HUX4401/89 19890825
- 主分类号: C07C251/58
- IPC分类号: C07C251/58 ; C07D213/16 ; C07D295/088
摘要:
The invention relates to novel racemic or optically active aminopropanol derivatives of formula I ##STR1## wherein R and R.sup.1 are independently hydrogen atom, halogen atom, lower alkoxy, or together represent a methylene dioxy group,R.sup.2 and R.sup.3 together represent a chemical bond or independently stand for a hydrogen atom,R.sup.4 and R.sup.5 are independently hydrogen atom, C.sub.3-7 cycloalkyl group or straight or branched, saturated or unsaturated C.sub.1-12 alkyl group optionally substituted by one or more dialkyl-aminoalkyl, dimethoxyphenyl or phenyl groups, orR.sup.4 and R.sup.5 together with the adjacent nitrogen atom form a 4 to 7 membered ring optionally comprising an oxygen, sulfur or a further nitrogen atom, which ring is optionally substituted by a phenyl, benzyl or C.sub.1-3 alkyl group and the said substituents may carry a hydroxyl group, one or two methoxy groups, halogen atoms or trifluoromethyl groups, orR.sup.4 and R.sup.5 together with the adjacent nitrogen atom form a piperidine ring which is optionally substituted by a phenyl or benzyl group and, if desired, it comprises a double bond,R.sup.6 stands for hydrogen atom or benzoyl group, andn represents an integer from 3 to 6,acid-addition salts and quaternary ammonium derivatives thereof.Further the invention relates to processes for preparing these compounds.The compounds of the invention exert cardiac circulation controlling and/or improving, central nervous system tranquillizing and/or digestive system irregulations improving effects.
公开/授权文献
- US4803930A Tables bolted to a wall 公开/授权日:1989-02-14
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