发明授权
- 专利标题： Aryl aliphatic acids
- 专利标题（中）： 芳基脂肪酸
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申请号： US894952申请日： 1992-06-08
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公开(公告)号： US5238832A公开(公告)日： 1993-08-24
- 发明人: Carl R. Johnson , Gilles Gorins , Kenneth V. Honn , Lawrence J. Marnett
- 申请人： Carl R. Johnson , Gilles Gorins , Kenneth V. Honn , Lawrence J. Marnett
- 申请人地址： MI Detroit TN Nashville
- 专利权人： Board of Governors of Wayne State University,Vanderbilt University
- 当前专利权人： Board of Governors of Wayne State University,Vanderbilt University
- 当前专利权人地址： MI Detroit TN Nashville
- 主分类号： A61K31/19
- IPC分类号： A61K31/19 ; C07C59/64 ; C07C323/56 ; C12P41/00
摘要：
Novel aryl aliphatic acids or derivatives thereof of the general formulaR--(C.sub.x --C.sub.y)--(C.sub.m H.sub.2m)--G--C(R.sup.1).sub.2 --Ar--(C.sub.n H.sub.2n)--COOR.sup.2are described which exhibit inhibiting activity against 12-lipoxygenase. The compounds are characterized by having a low level of toxicity. Also included are salts and esters of the aliphatic acids.
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