发明授权
- 专利标题: Carbocyclic derivatives
- 专利标题(中): 碳环衍生物
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申请号: US798125申请日: 1985-11-14
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公开(公告)号: US5241107A公开(公告)日: 1993-08-31
- 发明人: Kenneth W. Bair
- 申请人: Kenneth W. Bair
- 申请人地址: NC Research Triangle Park
- 专利权人: Burroughs Wellcome Co.
- 当前专利权人: Burroughs Wellcome Co.
- 当前专利权人地址: NC Research Triangle Park
- 优先权: GBX8428931 19841115
- 主分类号: C07C215/10
- IPC分类号: C07C215/10 ; C07C217/58 ; C07C217/74
摘要:
The present invention relates to compounds of formula (I)ArCH.sub.2 R.sup.1 (I)or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 30 carbon atoms in total); ethers, esters, thereof; acid addition salts thereof; wherein Ar is a C.sub.15-18 fused tetracarbocyclic ring system containing 3 or 4 aromatic rings or a C.sub.17-22 fused pentacarbocyclic ring system containing 4, or 5 aromatic rings, or a substituted derivative thereof; the ring system Ar should be planar or deviate only slightly from planarity. Thus, the ring system contains a maximum of two non-aromatic carbon atoms which may be in the same ring, in which case they are adjacent, or in different rings;Ar is not perylene, fluoranthene, chrysene, pyrene, or triphenylene;R.sup.1 contains not more than eight carbon atoms and is a group ##STR1## wherein m is 0 or 1; R.sup.5 is hydrogen;R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.1-5 alkyl optionally substituted by hydroxy;R.sup.8 and R.sup.9 are the same or different and each is hydrogen or C.sub.1-3 alkyl; ##STR2## is a five- or six-membered saturated carboxylic ring; R.sup.10 is hydrogen, methyl or hydroxymethyl;R.sup.11, R.sup.12 and R.sup.13 are the same or different and each is hydrogen or methyl;R.sup.14 is hydrogen, methyl, hydroxy, or hydroxymethyl.
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