发明授权
US5252474A Cloning genes from Streptomyces avermitilis for avermectin biosynthesis
and the methods for their use
失效
克隆来自阿维链霉菌的阿维菌素生物合成的基因及其使用方法
- 专利标题： Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
- 专利标题（中）： 克隆来自阿维链霉菌的阿维菌素生物合成的基因及其使用方法
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申请号： US490723申请日： 1990-03-14
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公开(公告)号： US5252474A公开(公告)日： 1993-10-12
- 发明人: Keith M. Gewain , Douglas J. MacNeil , Tanya MacNeil , Philip S. Paress , Carolyn L. Ruby , Stanley L. Streicher
- 申请人： Keith M. Gewain , Douglas J. MacNeil , Tanya MacNeil , Philip S. Paress , Carolyn L. Ruby , Stanley L. Streicher
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： C12N9/10
- IPC分类号： C12N9/10 ; C12N9/88 ; C12N15/10 ; C12N15/52 ; C12N15/76 ; C12P17/18 ; C12P19/62 ; C12N15/00 ; C12N15/11
摘要：
There are disclosed plasmids containing DNA isolated from Streptomyces avermitilis, the microorganism which is used to prepare avermectin compounds, identified as pAT1, pVE650 pVE855, pVE859, pVE1446, pVE923, and pVE924 which contain the genetic information for the biosynthesis of the avermectins. Methods for the isolation of such plasmid and for the manipulation of the plasmids to alter the formation of the avermectin compound are also disclosed.
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