A method for operating an electrophotographic proofing system for generating color proofs from image information during multiple imaging cycle proofing runs. Charge model information, development model information and toner replenishment model information are stored for each component color. Actual photoconductor charge characteristics are measured during the imaging cycles of the proofing runs. Actual toner characteristics from component color test patches developed during the imaging cycles are also measured. The photoconductor is charged during the imaging cycles as a function of the charge characteristics measured during a preceding imaging cycle for the same component color, and a as function of the charge model information for the color. The photoconductor is toned during imaging cycles as a function of toner characteristics measured from test patches during a preceding imaging cycle for the same component color and as a function of the development model information for the color. Working toner is replenished after the imaging cycles as a function of the development parameters used to tone the photoconductor during the imaging cycles for the same component color and as a function of the replenishment model information for the color. Charge model information and the development model information for each component color are updated as a function of measured values after the imaging cycles.