发明授权
US5264454A Certain 2-oxo-tetrahydro-cycloalkyl-benzopyran-3yl ureas having
acyl-CoA-cholesterol acyl transferase inhibitory activity
失效
具有酰基-CoA-胆固醇酰基转移酶抑制活性的某些2-氧代 - 四氢 - 环烷基 - 苯并吡喃-3-基脲
- 专利标题： Certain 2-oxo-tetrahydro-cycloalkyl-benzopyran-3yl ureas having acyl-CoA-cholesterol acyl transferase inhibitory activity
- 专利标题（中）： 具有酰基-CoA-胆固醇酰基转移酶抑制活性的某些2-氧代 - 四氢 - 环烷基 - 苯并吡喃-3-基脲
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申请号： US765182申请日： 1991-09-25
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公开(公告)号： US5264454A公开(公告)日： 1993-11-23
- 发明人: Kanji Meguro , Hiroyuki Tawada , Hitoshi Ikeda
- 申请人： Kanji Meguro , Hiroyuki Tawada , Hitoshi Ikeda
- 申请人地址： JPX Osaka
- 专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人地址： JPX Osaka
- 优先权： JPX2-259657 19900927; JPX3-202003 19910812
- 主分类号： A61K31/365
- IPC分类号： A61K31/365 ; A61K31/435 ; A61P3/06 ; A61P9/08 ; A61P9/10 ; C07D221/06 ; C07D221/08 ; C07D221/16 ; C07D311/78 ; C07D311/92 ; C07D311/94 ; A61K31/35
摘要：
Novel heterocyclic compound of the general formula: ##STR1## wherein ring A and ring B each means a benzene ring which is substituted or unsubstituted; X means a group of the formula: ##STR2## wherein R.sup.2 is hydrogen, an alkyl or an alkoxy; m is 0 or 1, the formula: ##STR3## wherein R.sup.3 is hydrogen or an alkyl, or the formula: --O--CO--; Y means a bond, --NH--, an C.sub.1 or 2 alkylene group or --CH.dbd.CH--; R.sup.1 means a hydrocarbon group which is substituted or unsubstituted; and n means a whole number of 3 through 6, or a salt thereof, having excellent acyl-CoA:cholesterol acyltransferase inhibitory activity, and a method for preparing it and its use.
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