发明授权
US5270306A Method of antagonizing excitatory amino acids by administration of
imidazobenzodiazepine compounds
失效
通过施用咪唑并二氮杂化合物拮抗兴奋性氨基酸的方法
- 专利标题： Method of antagonizing excitatory amino acids by administration of imidazobenzodiazepine compounds
- 专利标题（中）： 通过施用咪唑并二氮杂化合物拮抗兴奋性氨基酸的方法
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申请号： US703160申请日： 1991-05-20
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公开(公告)号： US5270306A公开(公告)日： 1993-12-14
- 发明人: Leif H. Jensen , Jorgen Drejer , Frank Watjen
- 申请人： Leif H. Jensen , Jorgen Drejer , Frank Watjen
- 申请人地址： DKX Glostrup
- 专利权人： NeuroSearch A/S
- 当前专利权人： NeuroSearch A/S
- 当前专利权人地址： DKX Glostrup
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; A01N43/62
摘要：
A method of antagonizing the biological effects of an excitatory amino acid of a subject in need of such antagonization comprising the step of administering to said subject an effective amount of a compound having the formula ##STR1## wherein R.sup.3 is hydrogen, C.sub.1-8 -alkyl which may be branched, or cycloalkylmethyl;R.sup.7 and R.sup.8 are independently hydrogen, halogen, CF.sub.3, CN, NO.sub.2, NH.sub.2, C.sub.1-4 -alkyl or C.sub.1-4 -alkoxy; andR.sup.4 is hydrogen and R.sup.5 is hydrogen or C.sub.1-7 -alkyl; or R.sup.4 and R.sup.5 together signify (CH.sub.2).sub.n wherein n is an integer of 2-3.
公开/授权文献
- US5708084A Organic polymers modified with silicone materials 公开/授权日：1998-01-13
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