发明授权
- 专利标题： Enantioselective production of chiral carboxylic acids
- 专利标题（中）： 对映选择性生产手性羧酸
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申请号： US966705申请日： 1992-10-26
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公开(公告)号： US5273895A公开(公告)日： 1993-12-28
- 发明人: Richard F. Rossi , Donald L. Heefner , Charles M. Zepp
- 申请人： Richard F. Rossi , Donald L. Heefner , Charles M. Zepp
- 申请人地址： MA Marlborough
- 专利权人： Sepracor, Inc.
- 当前专利权人： Sepracor, Inc.
- 当前专利权人地址： MA Marlborough
- 主分类号： C12P7/40
- IPC分类号： C12P7/40 ; C12P41/00 ; C12R1/01 ; C12R1/02 ; C12R1/025 ; C12R1/05 ; C12R1/06 ; C12R1/07 ; C12R1/13 ; C12R1/185 ; C12R1/38 ; C12R1/425 ; C12R1/66 ; C12R1/72 ; C12R1/85 ; C12N9/02
摘要：
A process for enantioselectively converting an aldehyde, a bisulfite adduct of an aldehyde or a glycidate to a chiral carboxylic acid is disclosed. The process utilizes a microorganism or an enzyme preparation from a microorganism and is particularly useful for producing NSAIDs of the profen class from readily available precursors. Preferred microorganisms are Gram-negative rod bacteria.
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