A main steam isolation valve of a reactor power plant comprises a valve body provided with inlet and outlet portions through which a steam flows, a cylindrical valve disk accommodated in the valve body to be reciprocatingly movable therein along an inner peripheral surface of the valve body for opening and closing the steam flow inlet portion and a driving mechanism secured to the valve body and operatively connected to the valve disk for reciprocatingly moving the valve disk in the valve body. A coupling member is applied to an end opening of the valve body for holding the valve disk when the valve disk is shifted to a position fully opening the inlet portion. A tubular wall member is integrally formed with the valve body so as to surround the valve disk with a gap therebetween when the valve disk is fully opened. A guide rib is further disposed to the valve body for causing asymmetric steam flow in the inlet portion of the steam flow of the valve body.