发明授权
US5281720A Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene
biosynthesis
失效
吡喃基苯基羟烷基萘甲酸作为白三烯生物合成的抑制剂
- 专利标题： Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis
- 专利标题（中）： 吡喃基苯基羟烷基萘甲酸作为白三烯生物合成的抑制剂
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申请号： US966204申请日： 1992-10-26
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公开(公告)号： US5281720A公开(公告)日： 1994-01-25
- 发明人: Robert N. Young , Yves Girard , John W. Gillard , Laird A. Trimble , John Scheigetz , James A. Yergey , Yves Ducharme , Deborah A. Nicoll-Griffith , John H. Hutchinson
- 申请人： Robert N. Young , Yves Girard , John W. Gillard , Laird A. Trimble , John Scheigetz , James A. Yergey , Yves Ducharme , Deborah A. Nicoll-Griffith , John H. Hutchinson
- 申请人地址： Kirkland
- 专利权人： Merck Frosst Canada, Inc.
- 当前专利权人： Merck Frosst Canada, Inc.
- 当前专利权人地址： Kirkland
- 主分类号： C07C65/24
- IPC分类号： C07C65/24 ; C07D295/096 ; C07D295/24 ; C07D309/06 ; C07D309/10 ; C07D309/30 ; C07D335/02 ; C07D493/08 ; A61K31/35 ; C07D311/94
摘要：
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis and allograft rejection and in preventing the formation of atherosclerotic plaques.