发明授权
US5292650A Preparation of hapalindole-related alkaloids from blue-green algae
失效
从蓝绿色藻类制备hapalindole相关生物碱
- 专利标题： Preparation of hapalindole-related alkaloids from blue-green algae
- 专利标题（中）： 从蓝绿色藻类制备hapalindole相关生物碱
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申请号： US946501申请日： 1992-09-16
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公开(公告)号： US5292650A公开(公告)日： 1994-03-08
- 发明人: Roseanne Bonjouklian , Richard E. Moore , Gregory M. L. Patterson , Tim A. Smitka
- 申请人： Roseanne Bonjouklian , Richard E. Moore , Gregory M. L. Patterson , Tim A. Smitka
- 申请人地址： IN Indianapolis HI Honolulu
- 专利权人： Eli Lilly and Company,University of Hawaii
- 当前专利权人： Eli Lilly and Company,University of Hawaii
- 当前专利权人地址： IN Indianapolis HI Honolulu
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A01N43/38 ; A01N43/90 ; A61K31/403 ; A61P31/04 ; A61P35/00 ; C07D209/56 ; C07D209/70 ; C07D209/80 ; C07D491/06 ; C07D491/08 ; C12N1/12 ; C12P17/08 ; C12P17/10 ; C12P17/18 ; C12R1/89 ; C12P17/16
摘要：
New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms.
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