An eyedrop applicator attachment for attachment to a bottle having a large or small threaded neck. The applicator attachment is provided with a hollow cylindrical body, and an eyecup integral with the body at one end. The other end of the body has an opening, and interiorly of the body are two female threads, located coaxially and of different diameters, the threads with the larger diameter being adjacent the open end of the body. Thus, the applicator attachment may be attached to a squeeze bottle with a larger diameter neck, or to a squeeze bottle with a smaller diameter neck. In an alternate embodiment, axially of the threads for engagement with the neck of a bottle, there is an extension having a third female thread, into which a plug is threaded to provide a closure for the nozzle of a bottle attached to the cylindrical body.In an alternate embodiment, the eyecup is integral with the neck of a bottle, which may be of molded plastic, and provided with a snap fitting for receiving a nozzle insert, there being a cylindrical extension between the neck portion of the bottle and the eyecup which is internally threaded to receive a stopper which is in part hollow to receive and engage with a surface thereof the end of the drop-forming nozzle.There are also provided an alternate embodiment in which a stopper and an attachment body have mating double threads, and the stopper has gripping means on the exterior or interior thereof. Further, a combined lid and stopper may be provided, with provision for relative sliding and rotatable movement.