发明授权
- 专利标题: Ultra pure hemoglobin solutions and blood-substitutes
- 专利标题(中): 超纯血红蛋白溶液和血液代用品
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申请号: US820153申请日: 1992-01-13
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公开(公告)号: US5296465A公开(公告)日: 1994-03-22
- 发明人: Carl W. Rausch , Mario Feola
- 申请人: Carl W. Rausch , Mario Feola
- 申请人地址: MA Boston
- 专利权人: Biopure Corporation
- 当前专利权人: Biopure Corporation
- 当前专利权人地址: MA Boston
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; A61M1/36 ; C07K14/805 ; A61K37/14 ; C07K3/02 ; C07K3/22 ; C07K15/22
摘要:
A blood substitute and plasma expander comprising a cross-linked, substantially endotoxin-free hemoglobin solution and process for preparing same. The process comprises fractionating whole blood, separating out a stromal-free, sterile hemoglobin solution, chromatographically separating endotoxins from said hemoglobin solution and crosslinking the resulting endotoxin-free hemoglobin solution.