发明授权
- 专利标题： N,N,N',N'-6-(1-piperazinyl)-2,5-pyridinediamines
- 专利标题（中）： N，N，N'，N'-6-（1-哌嗪基）-2,5-吡啶基亚胺
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申请号： US990729申请日： 1992-12-15
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公开(公告)号： US5302719A公开(公告)日： 1994-04-12
- 发明人: Andre Claussner , Jacques LeClaire , Lucien Nedelec , Daniel Philibert
- 申请人： Andre Claussner , Jacques LeClaire , Lucien Nedelec , Daniel Philibert
- 申请人地址： FRX
- 专利权人： Roussel Uclaf
- 当前专利权人： Roussel Uclaf
- 当前专利权人地址： FRX
- 优先权： FRX8903740 19890322
- 主分类号： C07D213/74
- IPC分类号： C07D213/74 ; C07J43/00 ; C07D401/00
摘要：
A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.A, R.sub.A.sup.1, R.sub.B R.sub.B.sup.1 are individually selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms or R.sub.A and R.sub.A.sup.1 or R.sub.B and R.sub.B.sup.1 together with the nitrogen atom to which they are attached form a 5- to 6-member heterocycle optionally substituted with alkyl of 1 to 3 carbon atoms and Y is hydrogen or ##STR2## wherein R.sub.6 is selected from the group consisting of hydrogen, --CH.sub.3, --F and --Cl, R.sub.9 and R.sub.11 form a second bond at 9(11) or R.sub.9 is hydrogen or --F and R.sub.11 is hydrogen, --OH or .dbd.0, R.sub.16 is --CH.sub.3 or hydrogen, R.sub.17 is hydrogen, --OH or acyloxy, the dotted lines indicate the possible presence of a second bond at 1(2) and 6(7)-positions and the wavy line indicates the .alpha.- and .beta.-position and their non-toxic, pharmaceutically acceptable acid addition salts having anti-inflammatory and antioxidant activity.
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