发明授权
US5306496A Antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3, process for
producing the same, and use of the same
失效
抗生素NK374186A，NK374186B，NK374186B3和NK374186C3，其制备方法及其用途
- 专利标题： Antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3, process for producing the same, and use of the same
- 专利标题（中）： 抗生素NK374186A，NK374186B，NK374186B3和NK374186C3，其制备方法及其用途
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申请号： US896676申请日： 1992-06-10
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公开(公告)号： US5306496A公开(公告)日： 1994-04-26
- 发明人: Tomio Morino , Masakazu Nishimoto , Mituyuki Nishide , Akira Masuda , Masatoshi Yamada , Eiji Kawano , Takaaki Nishikiori , Seiichi Saito
- 申请人： Tomio Morino , Masakazu Nishimoto , Mituyuki Nishide , Akira Masuda , Masatoshi Yamada , Eiji Kawano , Takaaki Nishikiori , Seiichi Saito
- 申请人地址： JPX Tokyo
- 专利权人： Nippon Kayaku Kabushiki Kaisha
- 当前专利权人： Nippon Kayaku Kabushiki Kaisha
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX3-195123 19910710
- 主分类号： C12P1/02
- IPC分类号： C12P1/02 ; A61K35/70
摘要：
Novel antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3 having antibacterial, antineoplastic, immunomodulation, and liver regeneration promoting activities are provided.NK374186A, NK374186B, NK374186B3 and NK374186C3 are obtained by culturing NK374186 strain (FERM P-12285) (FERM-BP 3870) belonging to the genus Penicillium. NK374186A is a compound represented by a rational formula of C.sub.34 H.sub.61 N.sub.3 O.sub.12 S.sub.9 and having a molecular weight of M+ 735 (FD-MS m/z); NK374186B is a compound represented by a rational formula of C.sub.34 H.sub.61 N.sub.3 O.sub.9 and having a molecular weight of M+ 655 (FD-MS m/z); NK374186B3 is a compound represented by a rational formula of C.sub.34 H.sub.61 N.sub.3 O.sub.9 and having a molecular weight of M+ 655 (FD-MS m/z); and NK374186C3 is a compound represented by a rational formula of C.sub.32 H.sub.59 N.sub.3 O.sub.7 and having a molecular weight of M+ 597 (FD-MS m/z).
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