发明授权
- 专利标题： Pharmaceutical compositions comprising novel oligopeptides exhibiting selective inhibiting effect upon the proliferation of hemopoietic cells
- 专利标题（中）： 包含对造血细胞增殖具有选择性抑制作用的新型寡肽的药物组合物
-
申请号： US750278申请日： 1994-05-17
-
公开(公告)号： US5312812A公开(公告)日： 1994-05-17
- 发明人: Andras Balazs , Istvan Schon , Tamas Szirtes , Lajos Kisfaludy, deceased
- 申请人： Andras Balazs , Istvan Schon , Tamas Szirtes , Lajos Kisfaludy, deceased
- 申请人地址： HUX Budapest
- 专利权人： Richter Gedeon Vegyeszeti Gyar Rt.
- 当前专利权人： Richter Gedeon Vegyeszeti Gyar Rt.
- 当前专利权人地址： HUX Budapest
- 优先权： HUX5745/90 19900903
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61P7/00 ; C07K5/10 ; C07K5/113 ; C07K7/06 ; A61K37/00
摘要：
The present invention relates to novel peptides of formulaeXaa Glu Asp Cys Lys (SEQ I.D. No: 1),andGlu Asp Cys Lys (SEQ I.D. No: 2)wherein the Cys sulfur is bonded to an acetamidomethyl group, and Xaa is pyro-Glu, the acid addition salts thereof, the pharmaceutical compositions comprising the same and a process for the preparation of the novel peptides and compositions.The novel peptides selectively inhibit the proliferation of hemopoietic cells.The invention also covers the treatment of mammals (including human beings) with the said peptides and compositions for selectively inhibiting the proliferation of hemopoietic cells.The advantage of the novel compounds is that they are almost completely harmless, they do not have any side-effect in therapeutic dose-range, in addition they significantly inhibit the damaging effects of drugs and radiation used for the therapy of tumorous diseases or the dose of drug or radiation can be increased when they are administered.
公开/授权文献
- US5941921A Sensor feedback control for automated bucket loading 公开/授权日：1999-08-24
信息查询
IPC分类:
