发明授权
US5314898A Aryl thiopyrano[4,3,2-cd]indoles as inhibitors of leukotriene
biosynthesis
失效
芳基噻喃[4,3,2-cd]吲哚作为白细胞三烯生物合成的抑制剂
- 专利标题： Aryl thiopyrano[4,3,2-cd]indoles as inhibitors of leukotriene biosynthesis
- 专利标题（中）： 芳基噻喃[4,3,2-cd]吲哚作为白细胞三烯生物合成的抑制剂
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申请号： US906062申请日： 1992-06-29
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公开(公告)号： US5314898A公开(公告)日： 1994-05-24
- 发明人: John Y. L. Chung , Robert A. Reamer , Yves Girard , Pierre Hamel
- 申请人： John Y. L. Chung , Robert A. Reamer , Yves Girard , Pierre Hamel
- 申请人地址： NJ Rahway CAX Kirkland
- 专利权人： Merck & Co., Inc.,Merck Frosst Canada Inc.
- 当前专利权人： Merck & Co., Inc.,Merck Frosst Canada Inc.
- 当前专利权人地址： NJ Rahway CAX Kirkland
- 主分类号： C07D495/06
- IPC分类号： C07D495/06 ; A61K31/44 ; C07D495/08
摘要：
Compounds having the formula I: ##STR1## are inhibitors of the 5-lipoxygenase enzyme and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, psoriasis, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
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