发明授权
- 专利标题： Azacyclic bisphosphonates as anticholesterolemic agents
- 专利标题（中）： 偶氮二磷酸盐作为抗胆固醇药
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申请号： US877574申请日： 1992-05-01
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公开(公告)号： US5317015A公开(公告)日： 1994-05-31
- 发明人: John W. Ullrich , Raymond D. Youssefyeh , Daniel L. Cheney , Christopher J. Burns
- 申请人： John W. Ullrich , Raymond D. Youssefyeh , Daniel L. Cheney , Christopher J. Burns
- 申请人地址： PA Collegeville
- 专利权人： Rhone-Poulenc Rorer Pharmaceuticals Inc.
- 当前专利权人： Rhone-Poulenc Rorer Pharmaceuticals Inc.
- 当前专利权人地址： PA Collegeville
- 主分类号： A61K31/66
- IPC分类号： A61K31/66 ; A61K31/675
摘要：
This invention relates to a method of lowering abnormally high serum cholesterol levels in the body without significantly reducing mevalonic metabolite synthesis and to novel pharmacological compositions containing as an active ingredient bisphosphonic acid and ester compounds containing a mono-, bi- or tricyclic ring linked with a bisphosphonate moiety through a basic amino alkylene group. This invention also provides novel bisphosphonate compounds and the processes for their preparation.