发明授权
- 专利标题: Quinobenzoxazine, antineoplastic agents
- 专利标题(中): 喹苯恶嗪,抗肿瘤药
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申请号: US842910申请日: 1992-02-27
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公开(公告)号: US5318965A公开(公告)日: 1994-06-07
- 发明人: Daniel T. Chu , Jacob J. Plattner , Robert Hallas
- 申请人: Daniel T. Chu , Jacob J. Plattner , Robert Hallas
- 申请人地址: IL Abbott Park
- 专利权人: Abbott Laboratories
- 当前专利权人: Abbott Laboratories
- 当前专利权人地址: IL Abbott Park
- 主分类号: C07D471/04
- IPC分类号: C07D471/04 ; A61K31/435 ; A61K31/535 ; A61K31/54 ; A61P35/00 ; C07D455/03 ; C07D471/06 ; C07D498/04 ; C07D498/06 ; C07D498/16 ; C07D513/04 ; C07D513/06
摘要:
Quinobenzoxazine, derivatives of the formula ##STR1## as well as the pharmaceutically acceptable salts, esters, amides and prodrugs thereof are disclosed, wherein R.sup.1 is hydrogen or a carboxy-protecting group, R.sup.2 and R.sup.3 are substitutents, A is oxygen, Z is a halogen or a nitrogen-containing group, X is hydrogen, halogen or alkyl, and W is hydrogen, alkyl, amino or halogen. The compounds have potent antineoplastic activity.
公开/授权文献
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