发明授权
- 专利标题： Oxazinone derivative
- 专利标题（中）： 恶嗪酮衍生物
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申请号： US956029申请日： 1992-12-10
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公开(公告)号： US5332734A公开(公告)日： 1994-07-26
- 发明人: Koji Kobayashi , Shunichi Manabe , Yoshihiro Watanabe , Kazuhide Hayakawa , Itsuo Uchida
- 申请人： Koji Kobayashi , Shunichi Manabe , Yoshihiro Watanabe , Kazuhide Hayakawa , Itsuo Uchida
- 申请人地址： JPX Tokyo
- 专利权人： Japan Tobacco, Incorporated
- 当前专利权人： Japan Tobacco, Incorporated
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX3-164060 19910410
- 主分类号： C07D265/22
- IPC分类号： C07D265/22 ; C07D413/12 ; C07D417/12 ; C07D471/04 ; C07D239/95 ; A61K31/535 ; A61K31/54 ; C07D239/72
摘要：
Disclosed is a novel oxazinone derivative represented by formula (I) given below or a pharmaceutically acceptable acid-addition salt thereof, which is useful as an anti-inflammatory agent, an agent for suppressing neutrophil infiltration and as a serine protease inhibitor: ##STR1## where A includes, for example, ##STR2## in which W is --O--, --S--, --CH.dbd.CH-- or --NR.sup.9 -- or means that (CH.sub.2).sub.n is directly bonded to (CH.sub.2).sub.n,V.sup.2 is .dbd.CR.sup.12 -- or .dbd.N--, andD is 5 to 7-membered carbon ring or hetero ring;X is --O--, --S--, --CO--, or --NR.sup.15 or means that A is directly bonded to (CH.sub.2).sub.l ;Y is --O--, --CH.dbd.CH-- or --NR.sup.16 -- or means that (CH.sub.2).sub.l is directly bonded to Z;Z is --CH.sub.2 -- or --CO--; andl is an integer of 0 to 4.Further, R and R.sup.1 to R.sup.16 are hydrogen atom, lower alkyl group, etc.
公开/授权文献
- US4205833A Bench vise 公开/授权日：1980-06-03
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